If you go with NixOS or guix, both of which are declaratively configured, you can swap 99.9% seamlessly. I run the same NixOS config on 2 machine and a VM. Only thing I had to modify between them are some driver specific settings, but those are easy to isolate.
I would say it’s actually easier in many cases. Nix has really fantastic packaging tooling. You do have to learn a bit of the nix language, however (not become an expert).
The issue comes when trying to build from source. In most other distros, ou just follow the readme. In nix, you have to package it.
That’s the project’s goal and they have 100% comparability across quite a few of the tools. Definitely still a ways to go before they can fully replace all of coreutils, but Ubuntu’s goal is to replace the tools peace meal with the once that are ready.